specific wavelength of ultraviolet (UV) light is not only extremely effective at killing the virus which causes COVID-19, but is also safer for use in public spaces, finds new University of Colorado Boulder research.
The study, published this month in Applied and Environmental Microbiology, is the first to comprehensively analyze the effects of different wavelengths of UV light on SARS-CoV-2 and other respiratory viruses, including the only wavelength safer for living beings to be exposed to without protection.
The findings, which the authors refer to as a "game changer" for UV light use, could lead to new affordable, safe and highly effective systems for reducing viral spread in crowded public spaces like airports and concert venues.
"Of almost every pathogen we have ever studied, this virus is one of the easiest, by far, to kill with UV light," said senior author Karl Linden, professor of environmental engineering. "It takes a very low dose. This indicates that UV technology could be a really good solution for protecting public spaces."
تنبعث الأشعة فوق البنفسجية بشكل طبيعي من الشمس ، ومعظم أشكالها ضارة بالكائنات الحية -- وكذلك الكائنات الحية الدقيقة ، مثل الفيروسات. يمكن أن يمتص جينوم الكائن الحي هذا الضوء ، ويربط العقد فيه ويمنعه من التكاثر. هذه الأطوال الموجية الضارة من الشمس يتم ترشيحها بواسطة طبقة الأوزون قبل أن تصل إلى سطح الأرض.
تستخدم بعض المنتجات الشائعة ، مثل مصابيح الأنبوب الفلوريسنت ، - ضوء الأشعة فوق البنفسجية المُعدّل هندسيًا ، بينما تحمي طبقة الفوسفور الأبيض من الداخل الأشخاص من الأشعة فوق البنفسجية.
"When we take that coating off, we can emit those wavelengths, and they can be harmful for our skin and our eyes -- but they can also kill pathogens," said Linden.
تستخدم المستشفيات بالفعل تقنية الأشعة فوق البنفسجية لتطهير الأسطح في الأماكن التي لا يوجد فيها أشخاص ، وذلك باستخدام الروبوتات التي يمكنها تسليط ضوء الأشعة فوق البنفسجية في غرف العمليات والمرضى بين الاستخدامات.
And many gadgets on the market today clean everything from cell phones to water bottles with UV light. But safety protocols are still being developed by the FDA and EPA. Linden cautions against using any personal or "germicidal" devices in which a person is exposed to UV light.
وقال إن النتائج الجديدة فريدة من نوعها ، لأنها ضربت النقطة المثالية بين ضوء الأشعة فوق البنفسجية الآمنة نسبيًا للبشر والمضرة بالفيروسات ، خاصة تلك التي تسبب COVID-19.
"This can be a game changer for the public use of UV light in indoor spaces," said Linden.
الموت بالتعرض
بالنسبة للدراسة ، قارن ليندن وفريقه جوانب مختلفة من الأطوال الموجية للأشعة فوق البنفسجية - حسب - الجانب باستخدام طرق قياسية تم تطويرها عبر صناعة ضوء الأشعة فوق البنفسجية.
"We thought, let's come together and make a definitive statement on what UV exposure is required to kill off SARS-CoV-2," said Linden. "We wanted to make sure that if UV light is being used to control disease, you're delivering the right dose that's protective of human health and human skin, but also going to be killing off these pathogens."
The opportunity to do this kind of work is rare, as there are extremely rigorous safety standards required to work with SARS-CoV-2. So Linden and Ben Ma, postdoctoral researcher in Linden's research group, collaborated with virologist Charles Gerba at the University of Arizona, at a lab cleared to work with the virus and its variants.
The researchers found that while the virus was quite susceptible to UV light in general, a specific wavelength of Far ultraviolet-C, at 222 nanometers, was particularly effective. Created by what's known as a krypton chloride excimer lamp, fueled by molecules moving between different states of energy, this wavelength is very high energy. Therefore, it's able to inflict greater viral protein and nucleic acid damage to the virus compared to other UV-C devices, as well as be blocked by the very top layers of human skin and eyes -- meaning that it has limited to no detrimental health effects at doses that are capable of killing off viruses.
"Not only is it safe, it's also the most effective," said Linden.
دور التطهير بالأشعة فوق البنفسجية اليوم
UV light in various forms has been used widely since the early 20th century to disinfect water, air and surfaces. As early as the 1940s, it was used to reduce the transmission of tuberculosis in hospitals and classrooms, by shining the light at the ceiling to disinfect air as it circulated throughout the room. Today, it's used not only in hospitals, but in some public bathrooms and airplanes when there are no people in those spaces.
In a recent White Paper published by the International UV Association, "Far UV-C Radiation: Current State-of Knowledge," which accompanies the new study, Linden and co-authors argue that this safer wavelength of Far UV-C light could serve as a key mitigation measure against the current and future pandemics, in addition to improved ventilation, mask wearing and vaccination.
يتخيل Linden الأنظمة التي يمكنها إما الدخول وإيقاف التشغيل في المساحات الداخلية لتنظيف الهواء والأسطح بشكل روتيني ، أو إنشاء حاجز مستمر وغير مرئي بين المعلمين والطلاب والعملاء وعاملي الخدمة والأشخاص في الأماكن التي لا يكون فيها التباعد الاجتماعي ممكنًا ، تطهير الهواء.
UV light disinfection can even rival the positive effects of improved indoor ventilation by providing the equivalent protection of increased air changes per hour within a room. It's also much cheaper to install UV lights than to upgrade an entire HVAC system.
"There is an opportunity here to save money and energy while protecting public health in the same way. It's really exciting," said Linden.
من المؤلفين الإضافيين في هذا المنشور ما يلي: Ben Ma of CU Boulder؛ باتريشيا جوندي وتشارلز جيربا من جامعة أريزونا ؛ ومارك سوبسي من جامعة نورث كارولينا في تشابل هيل.
